Pharmaceutica Analytica Acta

Sudha Srivastava

Publications

• Commentary
  Conformation of the Antigenic Peptide Tyrosinase (192-200) in Water and DMSO-d6 by NMR Spectroscopy and MD Simulations
  Author(s): Evans C Coutinho, Mishra NB, Deep Bhattacharya, Sudha Srivastava, Mamata Joshi and Mushtaque ShaikhEvans C Coutinho, Mishra NB, Deep Bhattacharya, Sudha Srivastava, Mamata Joshi and Mushtaque Shaikh
  
  Melanomas represent the most resistant form of cancer. If detected early, a cure is possible with the conventional therapies, while metastatic forms are almost resistant to conventional therapies. A new area i.e. immune based therapy shows promise of cytolytic activity against tumor cells. Production of antibodies against the antigenic epitopes present in the melanoma is the main basis of this immune based therapy. Production of T cell response against the tumor cells has been seen by synthetic antigenic epitopes. The antigenic nonameric peptide epitope of tyrosinase (192-200) with the sequence S1EIWR5DIDF9 causes significant induction of the T cell response in melanoma patients. In realm of the significance of this peptide, a solution state NMR structure of 192-200 amino acid section of tyrosinase has been investigated, to assimilate the relationship between the antigenicity and the .. View More»
  DOI: 10.4172/2153-2435.1000392

  Abstract PDF