Journal of Bioequivalence & Bioavailability

Subas ch. Parija

Publications

• Research Article
  Pharmacokinetic Profile of Nimesulide in Bovine Calves
  Author(s): Lombodar Mahapatra, Gyana R. sahoo, Monoj K. Panda and Subas ch. ParijaLombodar Mahapatra, Gyana R. sahoo, Monoj K. Panda and Subas ch. Parija
  
  The aim of the present study was to investigate pharmacokinetic profile and bioavailability of cyclooxygenase (COX)-2 selective nonsteroidal anti-infalmmatory drug nimesulide in bovine male calves after intravenous (i.v.) and intramuscular (i.m.) administration at a dose of 4.5mg/ kg BW. Blood samples were collected by jugular venipuncture at predetermined times following drug administration. Nimesulide in the plasma was assayed by using a validated HPTLC method. Plasma concentration-time data were subjected to compartmental analysis and pharmacokinetic parameters for nimesulide after i.v. and i.m. administration were calculated according to two and onecompartment open models, respectively. Following i.v. administration, a rapid distribution phase was followed by slower elimination phase. The half-lives during distribution phase (t1/2α) and terminal elimination phase (t1/2β.. View More»
  DOI: 10.4172/jbb.1000019

  Abstract PDF