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Stuaart M. Brooks
Stuaart M. Brooks
Colleges of Public Health and Medicine,
Tampa, Florida
Tanzania
Publications
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Review Article
Irritants, Irritancy and Irritant Induced Asthma
Author(s): Stuart M. Brooks Stuart M. Brooks
An irritant represents a non-corrosive chemical that causes a reversible non-immunologic inflammatory reaction after direct contact with the skin, eyes, nose and/or respiratory system. There are numerous reactions to irritants including change in spirometry, elevated exhaled breath levels of nitric oxide, enhancement of the response to allergen provocation and alteration of antioxidant defenses. Irritancy prompts an “inflammatory soup” of signaling molecules leading to tissue changes characterized by infiltration of mononuclear inflammatory cells, vascular congestion, augmented blood flow, contiguous edema with leaking of plasma, glandular hyper secretion and nervous hyperresponsiveness. Acute irritant-induced asthma, also referred to as Reactive Airways Dysfunction Syndrome (RADS), is a non-allergic type of asthma presenting without a prior time-period of latency. The man.. View More»
DOI: 10.4172/2155-6121.1000273