Journal of Carcinogenesis & Mutagenesis

Stephen Leonard

Publications

• Research Article
  Transcriptomics Evaluation of Hexavalent Chromium Toxicity in Human Dermal Fibroblasts
  Author(s): Rajendran Sellamuthu, Christina Umbright, Rebecca Chapman, Stephen Leonard, Shengqiao Li, Michael Kashon and Pius Joseph Rajendran Sellamuthu, Christina Umbright, Rebecca Chapman, Stephen Leonard, Shengqiao Li, Michael Kashon and Pius Joseph
  
  Significant exposure to hexavalent chromium, a metal with broad toxicity potential in humans, has been reported. In order to understand the mechanisms of dermal toxicity induced by hexavalent chromium, global gene expression profiling of human dermal fibroblasts exposed to potassium dichromate was performed. Microarray analysis of the gene expression profile in the fibroblasts treated with potassium dichromate identified significant differential expression of approximately 1,200 transcripts compared with the control cells. Functional categorization of the differentially expressed genes identified the enrichment of genes involved in several cellular processes, including apoptosis and oxidative stress, in the fibroblasts exposed to hexavalent chromium. Induction of apoptosis and oxidative stress in the dermal fibroblasts in response to their exposure to chromium was ind.. View More»
  DOI: 10.4172/2157-2518.1000116

  Abstract PDF