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Stefan Baron
Stefan Baron
Poland
Publications
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Research Article
An Assessment of the Impact of Zidovudine on Rat Teeth Ontogenesis with Quantitative Laser Induced Fluorescence and an Histomorphological Analysis
Author(s): MichaÅÂ Kaszuba Jr, Natalia Kaszuba, MichaÅÂ Kaszuba, Egle Milia, Teresa Kasprzyk, Armand Cholewka, Zofia Drzazga and Stefan Baron MichaÅ Kaszuba Jr, Natalia Kaszuba, MichaÅ Kaszuba, Egle Milia, Teresa Kasprzyk, Armand Cholewka, Zofia Drzazga and Stefan Baron
Objectives: It is known that many conditions may impact on dental organ development at foetus or new-born stages. The most important influence in this case is caused by genetic predispositions but also by drugs delivered prenatally and postnatally to the organism. The goal of this research was to find if the applications of Zidovudine to mothers’ organisms of rats can caused some abnormalities in dental organs of new-borns. Methods: The study was performed on 20 Wistar female rats and their 36 new-borns bred. The group of adult pregnant rats was divided on two sub-groups: with and without Zidovudine receiving. The influence of Zidovudine administered was assessed by using the quantitative laser-induced fluorescence and compared with the group without Zidovudine receiving as a reference subjects. Results: In result .. View More»
DOI: 10.4172/2161-1122.1000474