Journal of Vaccines & Vaccination

Soror Charedar

Publications

• Research
  Evaluation of New Leishmania Major Vaccine Against Immune Responses (Serum’s IL-17 and IL-23 and Spleen White Pulp Changes) Post Challenging with Leishmania Amastigotes in Balb/c Mice
  Author(s): Afshineh Latifynia1,2*, Mohammad Javad Gharagozlou3, Ahmad Masood1, Reza Agha Ebrahimi Samani3, Soror Charedar4, Mehdi Mohebali4Afshineh Latifynia1,2*, Mohammad Javad Gharagozlou3, Ahmad Masood1, Reza Agha Ebrahimi Samani3, Soror Charedar4, Mehdi Mohebali4
  
  Introduction: Leishmania is a protozoan parasite that has a life cycle in the form of an amastigote (in the mammalian body and in the middle of the macrophage) and promastigote in the mosquito saliva and culture medium with different antigenic determinant sites. Aim: Evaluation of new leishmania major vaccine against serum’s IL-17 and IL-23 and spleen white pulp changes post challenging with leishmania amastigotes survival rate of live mice was also evaluated for the second time after re-exposure. Result: Number of pulp spleen had almost significant differences between doses 100 and 200 μg/ml. LB group had lowest levels of IL-17, IL-23 and mouse weight and highest MPS, PSW/MW , number of pulp spleen and spleen weight was almost significant. LT group had highest levels of IL-23, whether, had lowest levels of mean pulp size, percent of spleen weight/mouse, and spleen weight was al.. View More»
  DOI: 10.4172/2157-7560.1000391

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