Journal of Bioequivalence & Bioavailability

Singh PR

Publications

• Research Article
  Antiangiogenic and Anti-invasive Effect of Diallydisulfide: An In-vitro Investigation Using Prostate Cancer Cell Line and In-vivo Using Zebrafish Embryo Model
  Author(s): Arunkumar R, Singh PR, Elumalai P, Sambantham S, Rani NJ, Dinakaran P and Arunakaran J Arunkumar R, Singh PR, Elumalai P, Sambantham S, Rani NJ, Dinakaran P and Arunakaran J
  
  Introduction: Prostate cancer is a major public health cancer worldwide, since it represents one in 10 cases of cancer in men and is of the highest incidence than any other cancers in India. Garlic has been extensively used as dietary supplements and as natural pharmaceutical in the treatment of various diseases including cancer. Methods: In-vitro Migration and Invasion assay used to assess the invasion and migration potential of cancer cells, upon treatment with DADS. In addition, using zebrafish embryo model anti-angiogenic potential of DADS was observed by RBC staining. Signaling molecules involved were analyzed using RT–PCR and Western bolt method respectively. Results: The result was found that DADS down-regulated PI3K/Akt and Ras/Raf signaling leading to down-regulation of MMPs and some pro-inflammatory.. View More»
  DOI: 10.4172/jbb.1000306

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