Journal of Bioequivalence & Bioavailability

Sinerik Ayrapetyan

Publications

• Review Article
  Na⁺/K⁺ Pump α₃ Isoform is a Universal Membrane Sensor for Weak Environmental Signals
  Author(s): Sinerik AyrapetyanSinerik Ayrapetyan
  
  In present review are presented data on functional role of α3-Na+/K+ pump isoform-dependent Ca exchange in weak signal transduction in cells. According to the classic “Membrane theory” signals can modulate membrane functional activity by changing its conductive function: activation or inactivation of ionic channels leading to cell membrane depolarization or hyper-polarization. However, at present it is well established that there are a number of non-conductive mechanisms in membrane through which extra-weak signals having intensity even far from the threshold of channel activation could modulate the cell membrane function. The previous study on the sensitivity of α3 receptors having higher ouabain affinity to different weak physical and chemical signals showed that they are universal sensors also for different environmental factors. Such sensitivity is d.. View More»
  DOI: 10.4172/jbb.1000131

  Abstract PDF