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Simona Steponkiene
Simona Steponkiene
Lithuania
Publications
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Research Article
Accumulation and Distribution of Non-targeted and Anti-CD44-conjugated Quantum Dots in Distinct Phenotypes of Breast Cancer
Author(s): Simona Steponkiene, Dominyka Dapkute, Una Riekstina and Ricardas RotomskisSimona Steponkiene, Dominyka Dapkute, Una Riekstina and Ricardas Rotomskis
Background: It has been postulated that most if not all cancers are hierarchically organized and contain distinct phenotypes of cells. In breast tumors CD44+/CD24-/EpCAM+ phenotype had been shown to possess the properties of cancer stem-like cells, while CD44low/-/CD24+/EpCAM+ cells represent more differentiated tumor cells that are often classified as luminal subtype of cancer. Quantum dots had already been used for imaging in vitro and in vivo, however the information about accumulation and time-dependent distribution of antibody-conjugated quantum dots in different phenotypes of breast cancer is still missing. Results: The accumulation and distribution of QDs was compared between CD44low/-/CD24+/EpCAM+ (MCF-7) and CD44+/CD24-/EpCam+ (MDA-MB-231) cells. The accumulation of non-targeted QDs was twofold more efficient in CD44low/-/CD24+/EpCAM+ cells than i.. View More»
DOI: 10.4172/2157-7439.1000341