Journal of Bioequivalence & Bioavailability

Si-Lan Wen

Publications

• Research Article
  Urinary Study on the Biochemical Effect of Acupuncture on Monosodium Urate Crystals-Induced Acute Gouty Arthritis in Rats using 600MHz 1H NMR
  Author(s): Yu Chen, Li-Ping Wu, Yu-Jie Liu, Peng-Chi Deng, Hai-Lin Yin, Si-Lan Wen, Cong Chen and Li-Ming YeYu Chen, Li-Ping Wu, Yu-Jie Liu, Peng-Chi Deng, Hai-Lin Yin, Si-Lan Wen, Cong Chen and Li-Ming Ye
  
  Acupuncture may potentially be an alternative therapy for acute gouty arthritis, a common inflammation model with multiple pathogenic mechanisms. In order to investigate the biological process of acute gouty arthritis and the effect of acupuncture, 1H nuclear magnetic resonance (NMR)-based metabonomics has been applied to acquire urine metabolom data. Acute gouty arthritis model rats were induced by monosodium urate (MSU) crystals. The acupuncture on ST-36 (Zusanli) and SP-6 (Sanyinjiao) acupoints was applied for nine consecutive days. Principal Components Analysis (PCA) and Partial Least Squares (PLS) have been used to compare the time course urine metabolic perturbations. The prominent changes in endogenous urinary metabolites in acute gouty arthritis rats comprised increased levels of citrate and succinate, and decrease of allantoin, lactate, formate, trimethyl-N-oxide (TMAO) and t.. View More»
  DOI: 10.4172/jbb.1000122

  Abstract PDF