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Sierdziński J
Sierdziński J
Poland
Publications
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Research Article
Hcc Angiogenic Propriety and Tumor Recurrence in Liver Transplant Recipients
Author(s): Otto WJ, HoÅówko WH, Krawczyk MS, Król MA, Wilkowojska UM, Wilczek E and SierdziÅski J Otto WJ, Hołówko WH, Krawczyk MS, Król MA, Wilkowojska UM, Wilczek E and Sierdziński J
Objective: Clinic-pathologic characteristic of hepatocellular carcinoma are mostly accounting for the tumor recurrence after liver transplantation. It is assumed that tumor angiogenesis capability contributes to the rates of post-transplant relapse, as well. The aim of study was to evaluate the contribution of the circulating hematopoietic stem cells (HSCs); endothelial progenitor cells (EPCs) and serum vascular endothelial growth factor (VEGF) to the recurrence of HCC after liver transplantation. Methods: The study was carried out on 49 cirrhotic patients with HCC within the Milan criteria. They were transplanted in 2009 and followed-up for 54 months, so far. The rates of circulating HSCs and EPCs were assessed through a phenotypic analysis of 2 ml of fresh blood in a flow cytometer. Serum VEGF concentration was measured by enzyme-linked immunoassay .. View More»
DOI: 10.4172/2153-2435.1000343