Journal of Stem Cell Research & Therapy

Shuen-Kuei Liao

Publications

• Review Article
  The Impact of Mesenchymal Stem Cell Source on Proliferation, Differentiation, Immunomodulation and Therapeutic Efficacy
  Author(s): Hui-Yun Cheng, Nicolae Ghetu, Christopher G Wallace, Fu-Chan Wei and Shuen-Kuei Liao Hui-Yun Cheng, Nicolae Ghetu, Christopher G Wallace, Fu-Chan Wei and Shuen-Kuei Liao
  
  Since their discovery almost 50 years ago, mesenchymal stem cells have shown great clinical potential in various clinical scenarios owing to their multilineage differentiation potential as well as immunomodulatory properties. However, recent studies indicate that properties of MSCs appear to be affected by factors such as their source. In this review, we focus on recent literature reporting direct comparisons of MSCs derived from different tissue sources, which include fetal MSCs from amniotic fluid, cord blood, umbilical cord and placenta, and adult MSCs from bone marrow, adipose tissue, heart, lung, synovial membrane and peripheral blood. It is demonstrated that MSCs from different sources showed variation in proliferation capacity, differentiation to various cells, immunomodulation capabilities, and efficacy of cell therapies in different scenarios.. View More»
  DOI: 10.4172/2157-7633.1000237

  Abstract PDF