Intellectual Property Rights: Open Access

Shreya Rajiv Bhargava

Publications

• Review Article
  Emergence of Tubulin as a Vaccine against Parasitic Infections
  Author(s): Shreya Rajiv Bhargava and Biswa Prasun Chatterji* Shreya Rajiv Bhargava and Biswa Prasun Chatterji*
  
  Tubulin, a conserved cytoskeletal protein, is a well-known drug target. It can also help in combating parasitic ailments. The sequence differences between parasitic and mammalian tubulin have led to the emergence of this protein as a vaccine against the causative agents of the widespread neglected tropical diseases (NTDs). Research on tubulin as a vaccine has resulted in many patented formulations in the past decade. The specific features of these patents (accessed from patent databases-WIPO, Espacenet, US PTO) encompass the source of tubulin, method of production, the vectors and host systems adopted, fusion partners chosen, the purification strategies, incorporation of adjuvants or carriers, route of administration and dosage. The chosen member of the tubulin superfamily for vaccine development is beta tubulin, owing to its variable C-terminus. Most of the patents outline isolation .. View More»
  DOI: 10.4172/2375-4516.1000124

  Abstract PDF