Advances in Pharmacoepidemiology and Drug Safety

Shiro Hinotsu

Publications

• Research Article
  A Survey of Non-Small Cell Lung Cancer Patients with Meningeal Carcinomatosis in Japan: Incidence and Medical Resource Consumption
  
  Author(s): Shinya Ohno, Shiro Hinotsu, Kyoko Murata, Shiro Tanaka and Koji Kawakami Shinya Ohno, Shiro Hinotsu, Kyoko Murata, Shiro Tanaka and Koji Kawakami
  
  Background: Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) may be effective for patients for non-small cell lung cancer (NSCLC) with meningeal carcinomatosis (MC), but evidence is limited particularly for the economics aspects. This study aimed to estimate the incidence of MC and resource consumption for NSCLC patients with MC as an exploratory study for further pharmacoeconomic evaluation of EGFR-TKI treatment in these patients. Methods: Patients diagnosed with NSCLC in Kyoto University Hospital between January 1, 2005 and December 31, 2008 was identified using medical record data in the hospital. The cumulative incidence of MC was calculated taking into account the competing risk of death. The economic analysis adopted the payer perspective and included direct medical costs (2010 costs) from the date of diagnosis of MC until the time of death. The .. View More»
  DOI: 10.4172/2167-1052.1000133

  Abstract