Cardiovascular Pharmacology: Open Access

Shiori Tamura

Publications

• Research Article
  High Susceptibility of Atherosclerotic Coronary Arteries to the Onset of Vasospasm and Angina Pectoris-like Symptoms due to Coronary Spasm in WHHLMI Rabbits
  Author(s): Tomonari Koike, Tatsuro Ishida, Shiori Tamura, Nobue Kuniyoshi, Ying Yu, Satoshi Yamada, Ken-ichi Hirata and Masashi Shiomi Tomonari Koike, Tatsuro Ishida, Shiori Tamura, Nobue Kuniyoshi, Ying Yu, Satoshi Yamada, Ken-ichi Hirata and Masashi Shiomi
  
  Objectives: We examined the relationship between atherosclerosis and provocation of coronary spasm as well as influence of coronary spasm on the onset of acute ischemic myocardial disease. Methods and Results: Coronary spasm was provoked in anesthetized normal Japanese white (JW) rabbits and WHHLMI rabbits, an animal model for coronary atherosclerosis and myocardial infarction, by injecting ergonovine during the infusion of norepinephrine through a marginal ear vein. A decrease in contrast flow in the left circumflex artery was observed on coronary angiograms. Ischemic changes were observed on the electrocardiogram of 29% (2/7) of JW and 79% (27/34) of WHHLMI rabbits. The frequency of coronary spasm was significantly high in rabbits with severe coronary plaques showing diffuse lesions. In addition, the degree of contraction of coronary strips w.. View More»
  DOI: 10.4172/2329-6607.1000131

  Abstract PDF