Journal of Vascular Medicine & Surgery

Sherif Sultan

Publications

• Research Article
  Assessment of Biocompatibility of the Multilayer Flow Modulator with Differing Thread Designs
  Author(s): Sherif Sultan, Edel P Kavanagh, Michel Bonneau, Chantal Kang, Antoine Alves4 and Niamh HynesSherif Sultan, Edel P Kavanagh, Michel Bonneau, Chantal Kang, Antoine Alves4 and Niamh Hynes
  
  Background: The Multilayer Flow Modulator (MFM) (Cardiatis, Isnes, Belgium) is a self-expandable mesh of cobalt alloy wires used for the treatment of aortic aneurysms. The impact of design thread count and duration of implantation on the biocompatibility of the MFM in porcine animal models was assessed in this study. Methods: Eight mini-piglets received 26 MFM devices (12 with 56 threads, 14 with 80-96 threads) in the iliac, carotid, and renal arteries. Animals were sacrificed and specimens explanted at 1, 3, and 6 months, at which time histological and ultrastructural analyses were carried out. Results: The MFM was successfully deployed in 25 of the 26 implanted cases. The 56 thread devices were well tolerated locally and yielded fewer signs of inflammation and neo intimal hyperplasia. Percentage stenosis was 16.9% &p.. View More»
  DOI: 10.4172/2329-6925.1000167

  Abstract PDF