Journal of Bioequivalence & Bioavailability

Shentu J

Publications

• Research Article
  Pharmacokinetics Analysis of Copen, a Novel Antitumor Semi Synthetic Derivative of Osthole, in Rats after Intragastric and Intravenous Administration
  Author(s): Zheng Y, Zhou H, Hu X, Wu G, Yanan L and Shentu JZheng Y, Zhou H, Hu X, Wu G, Yanan L and Shentu J
  
  Copen is one of the major semi synthetic derivatives of osthole with obvious antitumor activity. The absolute bioavailability and gender-related pharmacokinetic properties of copen in rats were determined in this study. Sprague-Dawley rats were intragastrically and intravenously administrated of different doses of copen, respectively. The concentrations of copen in rat plasma were determined by a LC-MS/MS method. Pharmacokinetic parameters were estimated using a drug and statistics (DAS) software. Statistical analysis was performed using independent two-sample t-test with p-values less than 0.05 as the level of significance. The results indicated that maximum plasma concentrations (Cmax) for copen were achieved at 9.17-14.17 min post-intragastric dosing; the elimination half-life (t1/2z) of copen after intragastric dosing was 196.55-302.16 min. After intra.. View More»
  DOI: 10.4172/jbb.1000325

  Abstract PDF