Journal of Nanomedicine & Nanotechnology

Sheng-I Lue

Publications

• Research Article
  The Immediate Mitochondrial Stress Response in Coping with Systemic Exposure of Silver Nanoparticles in Rat Liver
  Author(s): Tzu-Ying Lee, Maw-Shung Liu, Li-Ju Huang, Sheng-I Lue, Tsen-Ni Tsai, Lung-Chang Lin, Aij-Lie Kwan and Rei-Cheng YangTzu-Ying Lee, Maw-Shung Liu, Li-Ju Huang, Sheng-I Lue, Tsen-Ni Tsai, Lung-Chang Lin, Aij-Lie Kwan and Rei-Cheng Yang
  
  Silver nanoparticles (Ag-nps) induce hepatotoxicities via oxidative stress. The oxidative stress-induced mitochondrial damages are known to be regulated by mitochondrial unfolded protein response (mtUPR) and autophagy/mitophagy systems. The present study was undertaken to investigate role of mtUPR and autophagy/mitophagy on the Ag-nps induced mitochondrial dysfunction. Experiments consisted of two groups of Sprague Dawley rats: control and Ag-nps treated. The Ag-nps treated group received an intraperitoneally injection of 1.5 ml deionized water containing 500 mg/ kg of Ag-nps. Control group received equal volume of deionized water. All animals were sacrificed at different time points (6, 12, 18 and 24 hr post treatment), followed by removal of livers for determination of ATP content and protein expression. The results show that multi-ubiquitinated proteins (Ub-proteins) in liver mitoc.. View More»
  DOI: 10.4172/2157-7439.1000220

  Abstract PDF