Journal of Microbial & Biochemical Technology

Shashank Singh

Publications

• Review Article
  New Generation Antibiotics/Antibacterials: Deadly Arsenal for Disposal of Antibiotic Resistant Bacteria
  Author(s): Monica Sharma, Shashank Singh and Sidharth Sharma Monica Sharma, Shashank Singh and Sidharth Sharma
  
  Inappropriate prescribing, lack of compliance in taking medicines and wise spread uncontrolled use of drugs led to emergence of multidrug resistance in clinically important infectious agents. Over 480000 new cases of multidrug-resistant tuberculosis (MDR-TB) were reported by WHO in the year 2013 in hundred countries world wide. Therefore, there is an urgent need for new generation antibacterial which can effectively and precisely act on drug resistant bacteria. Different strategies of development of resistance in bacteria involve the changes at molecular level like mutations, over expression of enzymes and efflux. So, the strategies of antibiotics development can include methods which can counteract at molecular level like antisense antibacterial and inhibition of quorum sensing. Bacterial gene rpoD found in Staphylococcus species is highly conserved and became basis in creation of an.. View More»
  DOI: 10.4172/1948-5948.1000241

  Abstract PDF