Cardiovascular Pharmacology: Open Access

Sharapov NU

Publications

• Short Communication
  Atherosclerosis and Metabolic Syndrome-significance of Inflammation, Urgency of Weight Loss and Extracorporeal Removal of Proinflammatory and Proatherogenic Substances
  Author(s): Nazirov FG, Khaybullina ZR* and Sharapov NU Nazirov FG, Khaybullina ZR* and Sharapov NU
  
  The link between atherosclerosis and metabolic syndrome is through system inflammation. Molecular mechanisms of this link can be explained by hypothesis that arterial hypertension, central obesity and insulin resistance are connected through dysfunction of endothelium and inflammation, where major role play tumor necrosis factor alpha (TNF-a) and reactive oxygen species (ROS), that promotes modulation of insulin receptor substrare2 (IRS2) signaling, insulin resistance, nuclear factor NF-kB (NF-kB) and IκB kinase β activation, endothelial dysfunction, oxidized low density lipoproteins accumulation, vascular inflammatory responses with vascular smooth muscular cells apoptosis and atherosclerotic plaque instability. TNF-a and ROS overproduction closely linked with central obesity and adipocytokines deregulation. Morphological substrate of atherosclerosis-plaque, it’s sta.. View More»
  DOI: 10.4172/2329-6607.1000227

  Abstract PDF