Journal of Bioequivalence & Bioavailability

Shahzad Hussain

Publications

• Research Article
  Assessment of Bioavailability of Rifampicin as a Component of Anti-tubercular Fixed Dose Combination Drugs Marketed in Pakistan.
  Author(s): Shahzad Hussain, Farnaz Malik, Wajahat Mehmood, Abdul Hameed, Humanyun Riaz and Muhammad RizwanShahzad Hussain, Farnaz Malik, Wajahat Mehmood, Abdul Hameed, Humanyun Riaz and Muhammad Rizwan
  
  The World Health Organization (WHO) recommended DOTS program recommends treatment of TB with a combination of three to fi ve drugs. However, international bodies like the WHO and IUTLD (international union against tuberculosis and ling disease) recommend the use of only those fi xed dose combinations that have proven in vivo bioavailability. The present study was conducted to test the in vivo bioavailability of some of the formulations currently marketed in Pakistan on twenty six healthy volunteers as a three sequence, three period cross-over study. Rifampicin was administered in three different formulations out of which one (Formulation A) acted as a standard against which the other two formulations; Formulation B (Fixed dose combination without pyrazinamide) and formulation C (Fixed dose combination with pyrazinamide) were tested. Thirteen blood samples including a pre-dose sample w.. View More»
  DOI: 10.4172/jbb.1000033

  Abstract PDF