Journal of Bioequivalence & Bioavailability

Shahana Khattak

Publications

• Research Article
  Comparative Bioavailability Assessment of Newly Developed Flurbiprofen Matrix Tablets and Froben SR® Tablets in Healthy Pakistani Volunteers
  Author(s): Shahana Khattak, Farnaz Malik, Abdul Hameed, Safia Ahmad, Muhammad Rizwan, Humayun Riaz and Shahzad HussainShahana Khattak, Farnaz Malik, Abdul Hameed, Safia Ahmad, Muhammad Rizwan, Humayun Riaz and Shahzad Hussain
  
  Background: Flurbiprofen is a non-selective cyclo-oxygenase inhibitor, member of series of alkanoic acid derivatives, has anti-inflammatory, analgesic activity. Also used to treat gout, osteoarthritis, rheumatoid arthritis and is effective in inhibiting surgically induced miosis in human eyes while cataract extraction. Oral sustained release formulation as a novel matrix system of flurbiprofen tablets were prepared using Carboxy methylcellulose as release retardant. Objective: The aim of present study was comparative bioavailability assessment of newly developed flurbiprofen matrix tablets for sustained delivery, with commercially available Froben SR. Methods: Randomized, open-label, 2-periods, cross-over study conducted on 24 male healthy volunteers in Pakistan. Small batch of flurbiprofen matrix tablets were manufactured and evaluated according to Pharmacopoeial specifications. .. View More»
  DOI: 10.4172/jbb.1000047

  Abstract PDF