Journal of Nanomedicine & Nanotechnology

Sebastian Tacke

Publications

• Research Article
  The Influence of Silver Nanoparticles on the Blood-Brain and the Blood-Cerebrospinal Fluid Barrier in vitro
  Author(s): Sandra Cramer, Sebastian Tacke, Julia Bornhorst, Jürgen Klingauf, Tanja Schwerdtle and Hans-Joachim GallaSandra Cramer, Sebastian Tacke, Julia Bornhorst, Jürgen Klingauf, Tanja Schwerdtle and Hans-Joachim Galla
  
  The use of silver nanoparticles in medical and consumer products such as wound dressings, clothing and cosmetic has increased significantly in recent years. Still, the influence of these particles on our health and especially on our brain, has not been examined adequately up to now. We studied the influence of AgEO- (Ethylene Oxide) and AgCitrate-Nanoparticles (NPs) on the protective barriers of the brain, namely the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (blood-CSF) barrier in vitro. The NPs toxicity was evaluated by examining changes in membrane integrity, cell morphology, barrier properties, oxidative stress and inflammatory reactions. AgNPs decreased cell viability, disturbed barrier integrity and tight junctions and triggered oxidative stress and DNA strand breaks. However, all mentioned effects were, at least partly, suppressed by a Citrate-coating .. View More»
  DOI: 10.4172/2157-7439.1000225

  Abstract PDF