Journal of Blood Disorders & Transfusion

Schofield J

Publications

• Case Report
  Myocardial Infarction caused by Triple-Hit Lymphoma
  Author(s): Amanuel H, Schofield J and Kotoucek PP Amanuel H, Schofield J and Kotoucek PP
  
  Triple Hit Lymphoma (THL) is an extremely rare and aggressive form of Non-Hodgkin’s lymphoma with morphologic, phenotypic and genetic features of both diffuse large B cell lymphoma (DLBCL) and Burkitt’s lymphoma (BL). Its characteristic cytogenetic abnormalities involve chromosomal rearrangements of c-MYC, BCL-2, and BCL-6 genes. It has been recognised, in the 2016-revised WHO classification of lymphoid neoplasms, as “Highgrade B-cell lymphoma, with MYC and BCL2 and/or BCL6 rearrangements”. We describe a case of a 68 years old male with two years history of stable low-grade follicular lymphoma suddenly transforming into acute leukaemia caused by THL. During the aggressively progressive phase, he developed Non-ST Elevation MI (NSTEMI), diagnosed by raised troponin and new anterolateral ST depressions on his ECG. His MI was attributed to leukostasis, anaemia and .. View More»
  DOI: 10.4172/2155-9864.1000399

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