Journal of Bioequivalence & Bioavailability

Saxena P

Publications

• Research Article
  Novel Encapsulation of Lycopene in Niosomes and Assessment of its Anticancer Activity
  Author(s): Sharma PK, Saxena P, Jaswanth A, Chalamaiah M, Tekade KR and Balasubramaniam ASharma PK, Saxena P, Jaswanth A, Chalamaiah M, Tekade KR and Balasubramaniam A
  
  The lycopene is a naturally occurring bioactive constituent of Lycopersicum esculentum and its use in the prevention of cancer and diabetes. Developing effective therapy using a natural product like lycopene against cancer is an active area of research. The pure lycopene is susceptible to light, heat and oxidants, which limit its therapeutic applications. In the present investigation, a novel approach for lycopene encapsulation using glass wool (adsorptionhydration method) is represented. The niosome formulation was prepared to preserve the activity of lycopene and to improve the bioavailability. The niosomes were characterized by in vitro studies like entrapment efficiency, particle size, drug release profile, zeta potential, stability studies, etc., and in vivo bioavailability study. The anti-proliferative efficacy of formulation was evaluated against MC.. View More»
  DOI: 10.4172/jbb.1000300

  Abstract PDF