Journal of Stem Cell Research & Therapy

Satoshi Kainuma

Publications

• Research Article
  Promising Therapeutic Effects of Cell Sheet Implantation with a Pedicle Omentum Flap to Enhance the Angiogenic Response to Ischemic Cardiomyopathy
  Author(s): Yasuhiro Shudo, Shigeru Miyagawa, Satsuki Fukushima, Satoshi Kainuma, Atsuhiro Saito, Koichi Toda, Hiroyuki Nishi, Yasushi Yoshikawa, Akima Harada, Toshihiko Asanuma, Satoshi Nakatani, Tatsuya Shimizu, Teruo Okano and Yoshiki SawaYasuhiro Shudo, Shigeru Miyagawa, Satsuki Fukushima, Satoshi Kainuma, Atsuhiro Saito, Koichi Toda, Hiroyuki Nishi, Yasushi Yoshikawa, Akima Harada, Toshihiko Asanuma, Satoshi Nakatani, Tatsuya Shimizu, Teruo Okano and Yoshiki Sawa
  
  Introduction: We previously reported that skeletal myoblast (SMB) sheets induced the functional recovery of distressed myocardium in a large or small animal heart failure model via the paracrine effect of cytokines; however, this method was limited by poor vascular network and cell retention. We hypothesized that wrapping the cell sheet with pedicle omentum—a well-vascularized organ delivering different stem cell types and releasing various angiogenic and anti-inflammatory factors—might support retention of the implanted cells and enhance the therapeutic effects of the cell sheet technique on ischemic cardiomyopathy (ICM). Methods and results: The ICM model was generated by inducing anterior myocardial infarction for 4 weeks in mini-pigs; whereas the scaffold-free cell sheets were generated from autologous SMBs in vitro. The cell sheets were placed on the infarct area with.. View More»
  DOI: 10.4172/2157-7633.1000159

  Abstract PDF