Journal of Bioequivalence & Bioavailability

Sathirakul K

Publications

• Research Article
  Effect of α-mangostin on Enhanced Transdermal Bioavailability of Gartanin via Efflux Transporters
  Author(s): Rukthong P, Sereesongsang N, Kulsirirat T, Nimprayoon B and Sathirakul K Rukthong P, Sereesongsang N, Kulsirirat T, Nimprayoon B and Sathirakul K
  
  Mangosteen (Garcinia mangostana L) is a tropical evergreen tree growing in Southeast Asia and has been used as traditional medicine treatment for skin wounds and infection. The pericarp crude extract can be isolated to fifty xanthone compounds, α-, β and γ-mangostins, gartanin etc. This study aimed to characterize and compare the transdermal transport of α-mangostin and gartanin when used alone and co-administered in human epidermal keratinocyte cells, neonatal (HEKn cells). The concentrations of the compounds were determined of by LC-MS/MS. In the absorptive direction, gartanin could not be detected during the entire 8 hour. Moreover, apparent permeability coefficient in secretory direction (Papp, B-A) was significantly higher than that of absorptive direction (Papp, A-B) but not found in α-mangostin. The results showed that after incubating the HEKn cell.. View More»
  DOI: 10.4172/jbb.1000344

  Abstract PDF