Journal of Bioequivalence & Bioavailability

Sania Zehra

Publications

• Research Article
  Comparrative Assay of Citalopram in Different Media
  Author(s): Safila Naveed, Fatima Qamar, Syeda Sarah Abbas, Sania Zehra, Sehrish Kirn, Zohra Barkat and Syeda ZainabSafila Naveed, Fatima Qamar, Syeda Sarah Abbas, Sania Zehra, Sehrish Kirn, Zohra Barkat and Syeda Zainab
  
  Citalopram is one of a class of antidepressants known as selective serotonin reuptake inhibitors. Citalopram blocks the reuptake of serotonin at the serotonin reuptake pump of the neuronal membrane, enhancing the actions of serotonin on 5HT1A autoreceptors. SSRIs bind with significantly less affinity to acetylcholine, histamine and norepinephrine receptors than tricyclic antidepressant drugs Using UV spectrophotometer a simple, economical least time consuming and accurate method for comparison of different brand of citalopram, has been developed. The assay is based on the UV absorbance maxima at about wavelength of 244 nm using distilled water as solvent. Four different brand of citalopram was dissolved in buffer of pH 1, pH 4 and water and then various dilutions are prepared (200 ppm, 100 ppm, 50 ppm and 25 ppm). The absorbance of these drugs was measured at 244 nm against the solven.. View More»
  DOI: 10.4172/jbb.1000238

  Abstract PDF