Journal of Microbial & Biochemical Technology

Samantha J. Rinehart

Publications

• Research Article
  Synthesis and Characterization of a Chitosan/PVA Antimicrobial Hydrogel Nanocomposite for Responsive Wound Management Materials
  Author(s): Samantha J. Rinehart, Thomas D Campbell, Kevin J. Burke, Bianca Garcia, Amy Mlynarski, Samantha J. Brain, Julianne M. Truffa, James Rago, William E. Chura and Jason J Keleher Samantha J. Rinehart, Thomas D Campbell, Kevin J. Burke, Bianca Garcia, Amy Mlynarski, Samantha J. Brain, Julianne M. Truffa, James Rago, William E. Chura and Jason J Keleher
  
  The development of novel wound management materials must address several challenges to be most efficacious. Successful wound management should include the ability to adhere to wound surfaces, absorb wound exudates, and enhance bactericidal effectiveness. Few current biomaterials address all of these characteristics and in addition often have poor structural rigidity leading to a lack of protection and support to ensure proper cell growth. The focus of this study was to develop a multifunctional biomimetic nanocomposite system that will improve mechanical stability, effectively eliminate E. coli and S.aureus biofilm propagation, and serve as a scaffold for effective adult human dermal fibroblast (HDFa) growth. Synthetic parameters, such as the ratio of chitosan to PVA concentration and deposition method for the incorporation of Ag+-functionalized nanoparticles into the final nanocompos.. View More»
  DOI: 10.4172/1948-5948.1000264

  Abstract PDF