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Saleh KI
Saleh KI
Egypt
Publications
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Research Article
A Formulation, Optimization and Evaluation of Controlled Released Alginate Beads Loaded-Flurbiprofen
Author(s): Abdellatif AAH, El Hamd MA and Saleh KIAbdellatif AAH, El Hamd MA and Saleh KI
While flurbiprofen (FLB) may cause local gastrointestinal problems such as sensation of warming or burning in mouth and stomach, it is recommended to be limited its therapeutic uses or use it as a modified-release preparation for only once daily-use using Calcium-alginate (Ca-alginate) beads. Ca-alginate beads were prepared by dropping sodiumalginate solution containing FLB into calcium chloride solution. The prepared Ca-alginate beads loaded-FLB were characterized by optical-microscope at different positions. The weight and swelling percent of the beads were measured for freshly and dried prepared beads. The release of the formed beads was studied in different releasing medias. Finally, after optimizing all conditions the formed beads were used to reduce the paw edema as an anti-inflammatory dosage form. The release of FLB from the formed beads in a phosp.. View More»
DOI: 10.4172/2157-7439.1000357