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Sakthikumar D
Sakthikumar D
Bio-Nano Electronics Research Centre,
Saitama, Kawagoe
Japan
Publications
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Research Article
Evaluation of Toxicity of Maura Reduced Graphene Oxide using in vitro Systems
Author(s): Reshma S Cherian, Sreejith R, Syama S, Sruthi S, Gayathri V, Toru Maekawa and Sakthikumar DReshma S Cherian, Sreejith R, Syama S, Sruthi S, Gayathri V, Toru Maekawa and Sakthikumar D
The intriguing properties of graphene has paved way for many potential biomedical applications like drug delivery, tissue engineered scaffold, bio sensing and so on. Here, we report the interaction of Maura reduced graphene oxide (MRGO) with the peripheral blood mononuclear cells (PBMNCs), as there is a likelihood of graphene coming in contact with the blood through intentional or accidental exposure. MRGO was synthesized by reducing graphene oxide using Halomonas Maura and autoclaved subsequently to prevent microbial contamination. It was characterized by TEM, AFM and FITR. Initial cytotoxicity was conducted in L929 cells to get the dose response. Oxidative stress potential, effect on proliferative capacity, genotoxicity and induction of apoptosis in PBMNCs treated with MRGO were assessed. MRGO elicited a dose dependent ROS generation which promoted apoptosis in PBMNCs. Proliferation.. View More»
DOI: 10.4172/2157-7439.1000200