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Sahar Mohamed Kamal
Sahar Mohamed Kamal
Cairo
Egypt
Publications
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Research Article
Aliskiren Protects against Hypercholesterolemia and Oxidative Stress on Isolated Aortae in Cholesterol-Fed Rats
Author(s): Sahar Mohamed KamalSahar Mohamed Kamal
Background: Atherosclerosis and endothelial dysfunction are important associated disorders in the majority of hypertensive patients. Many studies are directed towards investigating any possible anti-hyperlipidemic effect with improvement of arterial compliance of newer generations of antihypertensive drugs so as to reduce the number of drugs used to treat those patients. Aim: The present study aims to determine the effects of aliskiren, a direct renin inhibitor, on serum cholesterol and some anti-oxidant enzymes together with aortic TBARS and vasorelaxant effect of acetyl-choline (Ach) on isolated aortic rings of cholesterol-fed rats. Methods: The duration of the study was 12 weeks. Twenty-four rats were randomly divided into 3 groups (n=8 rats/group). Group (1) is control, received 0.5% carboxymethylcellulose (CMC) sodium, as a solvent of aliskiren, and fed ordinary die.. View More»
DOI: 10.4172/2157-7439.S5-007