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Safeena Nazeer
Safeena Nazeer
Pakistan
Publications
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Research Article
Degradation Study of Metronidazole in Active and Different Formulation by UV Spectroscopy
Author(s): Safila Naveed, Nimra Waheed and Safeena NazeerSafila Naveed, Nimra Waheed and Safeena Nazeer
Metronidazole (MTZ) is a 5-nitroimidazole semi-synthetic compound. MTZ is antiamoebic, anti protozoal and antibacterial, anti parasitic and anti trichomonal agents. It has wide range of activity against anaerobic bacteria as gram negative, gram positive bacilli and cocci, certain capnophilic organisms, protozoa and parasites. It is indicated in infections caused by Helicobacter pylori, acne rosacea, anaerobic infections, parasitic infections, pseudomembranous colitis and Crohn’s disease. ICH guidelines states the parameters which causes forced degradation of a drug product includes Time, Temperature and/ or with humidity, Acid/base Stress testing, photo degradation and pH variation (high and low). Ultraviolet-visible spectroscopic process was developed to analyze and calculate the amount of drug in the presence of degradation products. According to the USP, the official assay li.. View More»
DOI: 10.4172/jbb.10000191