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Journal of Bioequivalence & Bioavailability

Saeed Ghanbarzadeh

Saeed Ghanbarzadeh

West Indies

Publications
  • Research Article
    Pharmacokinetic Study of Two Macrolide Antibiotic Oral Suspensions Using an Optimized Bioassay Procedure
    Author(s): Parvin Zakeri-Milani, Saeed Ghanbarzadeh, Farzaneh Lotfi poor, Morteza Milani and Hadi ValizadehParvin Zakeri-Milani, Saeed Ghanbarzadeh, Farzaneh Lotfi poor, Morteza Milani and Hadi Valizadeh

    Purpose: Erythromycin (ERY) (CAS 114-07-8) is a macrolide antibacterial with a broad and essentially bacteriostatic action and Azithromycin (AZI) (CAS 83905-01-5) is a semi-synthetic, acid stable erythromycin derivative with an expanded spectrum of activity and improved tissue pharmacokinetic characteristics relative to ERY. The aim of the present study was to develop an optimized procedure for determination of macrolide antibiotics in human serum as well as to compare the bioequivalence of two commercial brands of Erythromycin and Azithromycin Suspensions in healthy Iranian volunteers. Methods: Two brands of erythromycin ethylsuccinate and azithromycin oral suspensions were used. An equivalent 400-mg ERY suspension and 500-mg AZI suspension were given orally to each subject in two separate studies as a single dose with 200 ml of water. ERY and AZI concentrations in serum were deter.. View More»
    DOI: 10.4172/jbb.1000041

    Abstract PDF