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Sachin A. Thakare
Sachin A. Thakare
India
Publications
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Research Article
Development and Evaluation of Intranasal Mucoadhesiv Microspheres of Neostigmine Bromide
Author(s): Basavaraj K. Nanjwade, Kemy A. Parikh, Rucha V. Deshmukh, Veerendra K. Nanjwade, Kishori R. Gaikwad, Sachin A. Thakare and F. V.ManviBasavaraj K. Nanjwade, Kemy A. Parikh, Rucha V. Deshmukh, Veerendra K. Nanjwade, Kishori R. Gaikwad, Sachin A. Thakare and F. V.Manvi
Purpose: Neostigmine bromide, a cholinesterase inhibitor is conventionally given by oral route for the treatment of myasthenia gravis. However, it is very poorly absorbed from gastro-intestinal tract. Intranasal administration is an ideal alternative to the parenteral route for systemic drug delivery. Formulating multiparticulate system with mucoadhesive polymers may provide a significant increase in the nasal residence time. The aim of the present approach was to overcome the drawbacks of the conventional dosage forms of Neostigmine Bromide by formulating intranasal microspheres with Carbopol 974P NF and HPMC K15 M along with film forming polymer ethyl cellulose. Methods: The microspheres were prepared by emulsion solvent evaporation method. The prepared microspheres were characterized.. View More»
DOI: 10.4172/2153-2435.1000118