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Russell J. Mumper
Russell J. Mumper
Center for Nanotechnology in Drug Delivery, UNC Eshelman School of Pharmacy,
CB# 7355, 100G Beard Hall, Chapel Hill, North Carolina 27599-7355
Tanzania
Publications
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Research Article
Paclitaxel Nano-Delivery Systems: A Comprehensive Review
Author(s): Ping Ma and Russell J. MumperPing Ma and Russell J. Mumper
Paclitaxel is one of the most effective chemotherapeutic drugs ever developed and is active against a broad range of cancers, such as lung, ovarian, and breast cancers. Due to its low water solubility, paclitaxel is formulated in a mixture of Cremophor EL and dehydrated ethanol (50:50, v/v) a combination known as Taxol. However, Taxol has some severe side effects related to Cremophor EL and ethanol. Therefore, there is an urgent need for the development of alternative Taxol formulations. The encapsulation of paclitaxel in biodegradable and non-toxic nanodelivery systems can protect the drug from degradation during circulation and in-turn protect the body from toxic side effects of the drug thereby lowering its toxicity, increasing its circulation half-life, exhibiting improved pharmacokinetic profiles, and demonstrating better patient compliance. Also, nanoparticle-based delivery syst.. View More»
DOI: 10.4172/2157-7439.1000164