Pharmaceutica Analytica Acta

Rossi B

Publications

• Research Article
  Relationship between Elastic Properties and Gel-to-Sol Transition in Cyclodextrin-Based Hydrogel
  Author(s): Majolino D, Venuti V, Crupi V, Rossi B, Fontana A, Mele A, Melone L, Punta C, Trotta F, Giarola M and Mariotto GMajolino D, Venuti V, Crupi V, Rossi B, Fontana A, Mele A, Melone L, Punta C, Trotta F, Giarola M and Mariotto G
  
  In order to elucidate the effects of the nature of the cross-linker, of the hydration level and of the hydrophobic/ hydrophilic balance on the macro- and microscopic properties of a paradigmatic model of polysaccharide hydrogel, an integrated approach based on the combined use of low-frequency Raman scattering and FTIR-ATR absorption has been developed. The proposed methodology aims to explore the stability range of the liquid and gel phase diagram of the system. This approach was applied to cyclodextrin based nanosponges (CDNS), prepared by polymerization of α-, β-, and γ-cylcodextrins (CDNS) with an activated derivative of ethylenediamine tetra acetic acid. It revealed successful, on one side, for a comparative analysis of the elasticity, as mesoscopic parameter, of the dry polymeric network, measured by Raman spectroscopy in the low frequency (0 ÷ 150 cm&nda.. View More»
  DOI: 10.4172/2153-2435.1000356

  Abstract PDF