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Romina A Danguilan
Romina A Danguilan
Philippines
Publications
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Research Article
Effect of Methylprednisolone and Cyclophosphamide on the Survival of Patients with Leptospirosis, Renal Failure and Pulmonary Hemorrhage
Author(s): Rudi Joy T Manipol-Larano, Romina A Danguilan, Shalee Santos, Joselito Chavez and Myrna T MendozaRudi Joy T Manipol-Larano, Romina A Danguilan, Shalee Santos, Joselito Chavez and Myrna T Mendoza
Objectives: To determine the efficacy of three day methylprednisolone plus single dose intravenous cyclophosphamide on the survival of patients with leptospirosis, renal failure and pulmonary hemorrhage. Methods: A retrospective review of 138 patients diagnosed with leptospirosis at the National Kidney and Transplant Institute (NKTI) from August 1, 2009 to August 31, 2013 were included in the study. Patients were grouped according to those who received standard therapy with a 3-day course of Hydrocortisone (HC group) compared to a 3-day course of Methylprednisolone-Cyclophosphamide (MP-C). Patient survival, length of hospital stay and time to becoming dialysis independent were compared. Results: There were 65 patients in the HC group and 73 patients in the MP-C group. Mean age was 35.9 years, with male predominance. Th.. View More»
DOI: 10.4172/2329-9088.1000171