Journal of Bioequivalence & Bioavailability

Roberto F. Moreira

Publications

• Research Article
  Effect of Hyperlipemic Food on the Comparative Bioavailability of Two Bupropion Formulations after Administration of a Single Oral Dose of 150 mg in Healthy Human Volunteers
  Author(s): Roberto F. Moreira, Hamilton M. Rigato, Bruno C. Borges, Carlos E. Sverdloff, Rogério A. Oliveira, Ronilson A. Moreno and Ney C. BorgesRoberto F. Moreira, Hamilton M. Rigato, Bruno C. Borges, Carlos E. Sverdloff, Rogério A. Oliveira, Ronilson A. Moreno and Ney C. Borges
  
  A specific, fast and sensitive LC–MS/MS assay was d e- veloped for the determination of bupropion and its me- tabolite hydroxybupropion in human plasma using lidocaine as the internal standard. The limit of qu antifica- tion was 3.13 ng/ml for bupropion and 7.81 ng/ml fo r hydroxybupropion. The method was linear in the stud ied range of 3.13 – 400.00 ng/ml for bupropion and 7.81 – 1000 ng/ml for hydroxybupropion. This analytical me thod was applied to a comparative pharmacokinetic study, in which seventy eight volunteers (39 men and 39 femal e) aged between 18 and 50 years received a single oral dose of 150 mg of reference and test bupropion formulati on, in an open, two-period, balanced randomized, crossover pro- tocol. Group 1 received the medication without any addi- tional meal. Group two received a hyperlipemic meal 30 min before the medication. Based on the 90%.. View More»
  DOI: 10.4172/jbb.1000016

  Abstract PDF