Journal of Bioequivalence & Bioavailability

Rizea- Savu S

Publications

• Research Article
  Innovative Use of Medical Infrared Thermography to Evaluate Adhesive Properties of Two Buprenorphine Transdermal Patch Formulations in a Single Dose Adhesion Performance Study
  Author(s): Duna SN, Ghita A, Grasser S and Rizea- Savu S Duna SN, Ghita A, Grasser S and Rizea- Savu S
  
  An innovative approach for the assessment of transdermal patches adherence to the skin was developed and applied post-hoc to supportive imaging data collected in an open label, two-period, two-sequence, two-way crossover, controlled, randomized, single dose study to assess adhesion performance of two buprenorphine formulations (generic versus originator), applied topically to healthy male and female volunteers. The technology used for data acquisition is called Medical Infrared Thermography (MIT), a non-invasive, non-radiating imaging technique for surface temperature mapping. The use of this technology in an adhesion performance study was based on the rationale that the surface of a transdermal patch reaches a temperature in equilibrium with that of the body area where it is applied and whenever a discontinuity between skin and patch exists, the transmission of thermic energy to the .. View More»
  DOI: 10.4172/0975-0851.1000384

  Abstract PDF