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Rita Singh Majumdhar
Rita Singh Majumdhar
Greater Noida
India
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Research Article
Risk of Prostate Cancer and Cyclin D1 A870G polymorphism; a Study of Correlation
Author(s): Firdous Hussain, Arif Hamid and Rita Singh Majumdhar Firdous Hussain, Arif Hamid and Rita Singh Majumdhar
Cyclin D1 (CCND1) is a critical gene in regulating the progression of cell cycle from G1 to S phases. Like other cyclins, cyclin D1 is frequently dysregulated in multiple cancers. Various clinical and epidemiological studies have suggested the possible association of cyclin D1 A870G polymorphism with the development of various cancers. Hence, we investigated the role of cyclin D1 A870G polymorphism in modulating the risk of prostate cancer (CaP) in a Kashmiri population. We examined a case–control study in which 129 CaP cases were studied for cyclin D1 A870G polymorphism against 221 controls taken from the general population by employing the polymerase chain reaction–restriction length fragment polymorphism technique. We observed the cyclin D1 A allele was more frequently present in the CaP group than the contr.. View More»
DOI: 10.4172/2157-2518.1000293