Journal of Infectious Diseases and Diagnosis

Rihito Watanabe

Publications

• Research Article
  Induction of Anti-inflammatory Cytokines in CD11b- and Gr-1- Positive Cells after Neuropathogenic Coronaviral Infection
  Author(s): Masatoshi Kakizaki, Akira Togayachi and Rihito Watanabe* Masatoshi Kakizaki, Akira Togayachi and Rihito Watanabe*
  
  Mu-3 virus (Mu-3), a neuropathogenic strain of the mouse hepatitis virus, induces the apoptosis of pyramidal neurons in CA2 and CA3 subregions of the hippocampus at 4 days post-inoculation (dpi), without showing destructive changes or viral invasion there at 3 dpi. Since it has been considered that the apoptotic lesions occur through the indirect effects of infection, local expression of cytokines was examined in the brain in our previous study, revealing that the anti-inflammatory cytokine IL-10 is produced by pyramidal neurons of CA2 and CA3 after infection. However, infection of primary brain culture failed to elevate IL-10 production. Therefore, in order to examine whether Mu-3 infection elevates IL-10 production, CD11b-expressing Peritoneal Exudate Cells (PECs) were used, which showed an increased level of IL-10 production in the supernatant of PEC culture after infection. The fi.. View More»
  DOI: 10.4172/2576-389X.1000112

  Abstract PDF