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Richard M Kream
Richard M Kream
Tanzania
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Research Article
Evolutionary Perspective on Microglial/Neuronal Coupling with Special Relevance to Psychiatric Illnesses
Author(s): George B Stefano and Richard M KreamGeorge B Stefano and Richard M Kream
Microglia have selectively evolved as a morphologically and chemically distinct class of immuno-competent CNS resident cells with potent bidirectional signaling capabilities linked to induction of a macrophage-like phenotype following metabolic, microbiological, or viral insults. It has been empirically determined that a conserved set of shared chemical messengers connects a communication network mediating reciprocal exchange of regulatory information between immune, central nervous, and neuroendocrine systems. From an evolutionary perspective, the pluripotent neuro-protective capabilities of invertebrate microglia have been extended and amplified in classes of mammalian microglia. The state-dependent plasticity of microglia has provoked considerable empirical investigation into their functional/regulatory roles in mediating innate immune surveillance and .. View More»
DOI: 10.4172/2378-5756.1000329