Journal of Bioequivalence & Bioavailability

Richard Fruncillo

Publications

• Research Article
  Effects of Age and Sex on the Pharmacokinetics, Safety, and Tolerability of Oral Desvenlafaxine in Healthy Adults
  Author(s): Alice I Nichols, Lyette S Richards, Jessica A Behrle, Joel A Posener, Richard Fruncillo and Jeffrey Paul Alice I Nichols, Lyette S Richards, Jessica A Behrle, Joel A Posener, Richard Fruncillo and Jeffrey Paul
  
  Background: Desvenlafaxine (administered as desvenlafaxine succinate) is a serotonin-norepinephrine reuptake inhibitor approved for treatment of major depressive disorder. Because it is primarily eliminated unchanged by renal excretion, it is important to characterize the effect of patient factors, such as age and sex that may influence renal clearance. Methods: The pharmacokinetics, safety, and tolerability of a single oral dose of desvenlafaxine were assessed in healthy adults stratified by age (young, 18-45 years; elderly, 65-75; very old, >75) and sex in an open-label, inpatient trial. Results: Desvenlafaxine was generally well tolerated and was slowly absorbed in all age groups. Mean values for peak plasma concentration (C max ) for women exceeded those of men (P<0.001), and women had a shorter time to C max (P=0.011). Compared with young p.. View More»
  DOI: 10.4172/jbb.1000140

  Abstract PDF