Journal of Membrane Science & Technology

Reo Makihara

Publications

• Research Article
  Effects of Benzoic Acid and its Analogues on Osmotic Fragility in Guinea Pig Erythrocytes In Vitro
  Author(s): Hitoshi Mineo, Kazuki Kasai, Reo Makihara and Tomoya YuukiHitoshi Mineo, Kazuki Kasai, Reo Makihara and Tomoya Yuuki
  
  In our previous report, benzoic acid and some of its chemical analogues were shown to increase osmotic fragility (OF) in isolated rat red blood cells (RBCs). However, there have been no reports on the effects of benzoic acid and its derivatives on OF in the RBCs of other animals. To clarify these inter-species differences, the effects of those chemicals on OF were examined in guinea pig RBCs. The isolated RBCs were exposed to the chemicals at a concentration of 0.1-100 mM for 1 h. OF was measured by determining the 50% hemolysis of RBCs using a 0.1-0.8% NaCl solution. Benzoic acid and some of its derivatives decreased OF in a dose dependent manner. Replacement of the carboxylic group with another group or the introduction of another element on the benzene ring also affected OF. These effects were dependent on both the type of molecule and the position at which they were introduced int.. View More»
  DOI: 10.4172/2155-9589.1000161

  Abstract PDF