Journal of Bioequivalence & Bioavailability

Renata Pereira

Publications

• Research Article
  Gabapentin Bioequivalence Study: Quantification by Liquid Chromatography Coupled to Mass Spectrometry
  Author(s): Eduardo Abib Junior, Luciana Fernandes Duarte, Renata Pereira, Joseane Montagner Pozzebon, Deo Tosetti and Juliana Marise Cardoso CustódioEduardo Abib Junior, Luciana Fernandes Duarte, Renata Pereira, Joseane Montagner Pozzebon, Deo Tosetti and Juliana Marise Cardoso Custódio
  
  The study was performed to compare the bioavailability of two gabapentin 400 mg capsule formulation (Gabapentin from Arrow Farmacêutica S/A as test formulation and Neurontin ® from Pfizer, Brazil, as reference formulation) in 26 volunteers of both sexes. The study was conducted open with randomized two period crossover design and a one week wash out period. Plasma samples were obtained over a 48 hour interval. The gabapentin was analyzed by LC/MS/MS, in the presence of pracetamole as internal standard. With plasma concentration vs. time curves, data obtained from this metabolite, the following pharmacokinetics parameters were obtained: AUC 0-t , AUC 0-inf and C max . Geometric mean of gabapentin/Neurontin ® 400 mg individual percent ratio was 100.58% AUC 0-t , 101.35% for AUC 0-inf and 97.76% for C max . The 90% confidence intervals were 92.00 – 109.95%, 93.00 .. View More»
  DOI: 10.4172/jbb.1000083

  Abstract PDF