Biology and Medicine

Reagan J Major

Publications

• Hypothesis
  Mechanism of Synaptic Dysfunction and How This Disruption in IGF-1 homeostasis Leads to Neurodegenerative Diseases: A Theory
  Author(s): Reagan J Major and Adrian A Jarquin-ValdiviaReagan J Major and Adrian A Jarquin-Valdivia
  
  Background: The diverse stimuli which ultimately trigger synaptic degeneration, may do so through a single, critical step or related pathways. The identification of such a step could possibly result in a significant breakthrough in our understanding of why synapses are particularly vulnerable. This could assist in the development of clinical strategies that protect synaptic function, possibly providing answers for a broad spectrum of disorders. Methods: We propose that the methodology behind the mystery of synaptic disintegration is found in the 4- dimensional aberrant neurological function. In the CNS this presents as delirium, in the PNS fragility (acquired hospital weakness). Results: Clinically, we observe that the loss of synaptic function may occur faster than the recovery of the neurological circuit, causing.. View More»
  DOI: 10.4172/0974-8369.1000445

  Abstract PDF