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Razygraev AV
Razygraev AV
St Petersburg State Chemical Pharmaceutical Academy,
St Petersburg
Serbia
Publications
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Short Communication
Decreased Activity of Thiol Peroxidase (Glutathione Peroxidase 3) in Blood Plasma as an Indicator of Aging
Author(s): Razygraev AV Razygraev AV
Thiol peroxidases is a superfamily of antioxidant enzymes catalyzing the thiol-dependent reduction of hydroperoxides. Thiol peroxidases of glutathione peroxidase (Gpx) family utilize reduced glutathione (GSH) as a reductant. Early studies recognized that plasma selenium-dependent Gpx (Gpx3) possesses a wide thiol specificity. Our previous study statistically confirmed the ability of rat Gpx3 to utilize reduced homocysteine (Hcy-SH) instead of GSH. Thus, GSH can be completely replaced by Hcy-SH in a reaction mixture, that allows to determine Gpx3 activity with higher selectivity. In present study, the hypothesis of the age-associated decline of thiol peroxidase activity in rat plasma was tested using Hcy-SH as a thiol substrate. The enzymatic activity in 23-24-month-old rats was significantly lower than in 6-8-month-old rats (p=0.0012, Wilcoxon-Mann-Whitney test). These data are in agr.. View More»
DOI: 10.4172/2167-7182.1000411