Journal of Bioequivalence & Bioavailability

Ramin Darvair

Publications

• Research Article
  Decreased Subcutaneous Bioavailability of an Oxyntomodulin Analog in a Controlled Release Formulation could be Caused by Skin Metabolism in Rats
  Author(s): Mengmeng Wang, David Defranco, Katherine Wright, Shakey Quazi, Jianqing Chen, Jennifer Spencer-Pierce, Iman Zaghloul, Roger Pak, Ramin Darvair, Aadithya Krishnan, Mylene Perreault, Lei Sun, Josef Ozer and Xin XuMengmeng Wang, David Defranco, Katherine Wright, Shakey Quazi, Jianqing Chen, Jennifer Spencer-Pierce, Iman Zaghloul, Roger Pak, Ramin Darvair, Aadithya Krishnan, Mylene Perreault, Lei Sun, Josef Ozer and Xin Xu
  
  Objectives In vivo and in vitro studies were conducted to understand the potential cause for the reduced bioavailability of Peptide A, an Oxyntomodulin analog, following subcutaneous administration in the controlled release formulation compared to that in the instant release formulation, in spite of a prolonged half-life achieved by the controlled release formulation. Methods Concentrations in plasma, urine, feces and/or a panel of tissues including skin were measured after intravenous or subcutaneous administration of Peptide A or [I125] Peptide A to rats. Dose recovery, pharmacokinetic parameters and skin absorption kinetics were estimated. In vitro skin stability in rats was also performed for [I125] Peptide A. HPLC radio chromatography was used to elucidate peptide degradation in skin from in vivo and in vitro studies... View More»
  DOI: 10.4172/jbb.10000115

  Abstract PDF