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Ramesh Bomma
Ramesh Bomma
SRR College of Pharmaceutical Sciences,
Elkathurthy, Karimnagar, Telangana
India
Publications
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Research Article
Amoxycillin Trihydrate Floating-Bioadhesive Drug Delivery System for Eradication of Helicobacter pylori: Preparation, In Vitro and Ex Vivo Evaluation
Author(s): Narendar Dudhipala, Arjun Narala, Karthik Yadav Janga and Ramesh BommaNarendar Dudhipala, Arjun Narala, Karthik Yadav Janga and Ramesh Bomma
The aim of the present investigation was to formulate and evaluate floating-bioadhesive tablets of amoxicillin trihydrate (ATFBT), to provide local action in the treatment of Helicobacter pylori (H. pylori) by prolonging the gastric residence time. The FBT were prepared by direct compression method using hydroxy propyl methyl cellulose (HPMC K4M) / chitosan (CH), carbopol (CP974P) / polymethacrylic acid (PMA) as release retarding agent / bioadhesive respectively, sodium bicarbonate (NaHCO3) as a gas-former. The prepared tablets were evaluated for their physical characters such as drug content, in vitro buoyancy, swelling index, drug release and stability. Further, the bioadhesive strength (BS) was determined using porcine gastric mucosa. DSC studies indicate the compatibility of the drug and excipients used in the formulation. The floating lag time, total .. View More»
DOI: 10.4172/jbb.1000280